Metformin is not only the most useful medication for people with type 2 diabetes, but also one of the most useful and cost-effective medications in all of healthcare. Really the only problem with metformin is if you experience a side effect (abdominal distress, diarrhea, nausea, indigestion). The good news about these side effects is that they are not a sign that something more serious is going on inside your body; metformin does not cause damage to any of your bodies organs or tissues. The bad news is that these side effects can be quite uncomfortable, and there is no clear substitute medicine for metformin, since it is the only available medication in its family. However, this paper outlines several approaches; retrying metformin at a lower dose, using a once a day, slow release form, metformin XR, or even trying some foods similar to probiotics that can change the bacteria in your gut. The most useful approach is switching to the slow release form of metformin.